New and bioactive lignans from the fruits of Schisandra sphenanthera
Phytochemical investigation of the ethanol extract from the fruits of Schisandra
sphenanthera has resulted in isolation of seven new oxygenated lignans (1–7), in addition
to 11 known compounds (8–18). Their structures were determined on the basis of 2D-NMR
(COSY, HMQC, HMBC and NOESY) analyses. The isolated components were evaluated
with a reporter gene assay that measures their anti-liver fibrosis activity. Compounds 1, 2, 4,
11, 13, 14 and 18 exhibited significant anti-inflammatory activity on HSC-T6 test.
sphenanthera has resulted in isolation of seven new oxygenated lignans (1–7), in addition
to 11 known compounds (8–18). Their structures were determined on the basis of 2D-NMR
(COSY, HMQC, HMBC and NOESY) analyses. The isolated components were evaluated
with a reporter gene assay that measures their anti-liver fibrosis activity. Compounds 1, 2, 4,
11, 13, 14 and 18 exhibited significant anti-inflammatory activity on HSC-T6 test.
New and bioactive lignans from the fruits of Schisandra sphenanthera.
HHC Huang HsinChan, LYC Lin YuChi, AE Fazary… - 2011 - cabidigitallibrary.org
Phytochemical investigation of the ethanol extract from the fruits of Schisandra
sphenanthera has resulted in isolation of seven new oxygenated lignans (1-7), in addition to
11 known compounds (8-18). Their structures were determined on the basis of 2D-NMR
(COSY, HMQC, HMBC and NOESY) analyses. The isolated components were evaluated
with a reporter gene assay that measures their anti-liver fibrosis activity. Compounds 1, 2, 4,
11, 13, 14 and 18 exhibited significant anti-inflammatory activity on HSC-T6 test.
sphenanthera has resulted in isolation of seven new oxygenated lignans (1-7), in addition to
11 known compounds (8-18). Their structures were determined on the basis of 2D-NMR
(COSY, HMQC, HMBC and NOESY) analyses. The isolated components were evaluated
with a reporter gene assay that measures their anti-liver fibrosis activity. Compounds 1, 2, 4,
11, 13, 14 and 18 exhibited significant anti-inflammatory activity on HSC-T6 test.
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