New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses
D Zhang, W Yang, N Degauque, Y Tian, A Mikita… - Blood, 2007 - ashpublications.org
Recent studies have demonstrated that in peripheral lymphoid tissues of normal mice and
healthy humans, 1% to 5% of αβ T-cell receptor–positive (TCR+) T cells are CD4−
CD8−(double-negative [DN]) T cells, capable of down-regulating immune responses.
However, the origin and developmental pathway of DN T cells is still not clear. In this study,
by monitoring CD4 expression during T-cell proliferation and differentiation, we identified a
new differentiation pathway for the conversion of CD4+ T cells to DN regulatory T cells. We …
healthy humans, 1% to 5% of αβ T-cell receptor–positive (TCR+) T cells are CD4−
CD8−(double-negative [DN]) T cells, capable of down-regulating immune responses.
However, the origin and developmental pathway of DN T cells is still not clear. In this study,
by monitoring CD4 expression during T-cell proliferation and differentiation, we identified a
new differentiation pathway for the conversion of CD4+ T cells to DN regulatory T cells. We …
New differentiation pathway for double-negative regulatory T-cells that regulates the magnitude of immune responses (87.9)
D Zhang, W Yang, N Degauque, Y Tian… - The Journal of …, 2007 - journals.aai.org
… DN T-cells converted from CD4 + T-cells exerted powerful inhibition on same, but not
third party, alloantigen triggered proliferation of naïve T cells. Perforin, a cytotoxic
lymphocyte related cytokine, was highly expressed by DN … This previously unknown
pathway of differentiating DN regulatory T-cells represents a negative feedback mechanism
of immune response. The results of using ex vivo CD4 + T-cells converted DN T-cells in
transplantation and autoimmune disease models support the concept and the feasibility of …
third party, alloantigen triggered proliferation of naïve T cells. Perforin, a cytotoxic
lymphocyte related cytokine, was highly expressed by DN … This previously unknown
pathway of differentiating DN regulatory T-cells represents a negative feedback mechanism
of immune response. The results of using ex vivo CD4 + T-cells converted DN T-cells in
transplantation and autoimmune disease models support the concept and the feasibility of …