New insights into the crossroads between EMT and stemness in the context of cancer
I Fabregat, A Malfettone, J Soukupova - Journal of clinical medicine, 2016 - mdpi.com
The epithelial-mesenchymal transition (EMT) is an example of cellular plasticity, where an
epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and
invasive properties. Stemness is the ability of stem cells to proliferate in an asymmetric way
that allows them to maintain the reservoir of undifferentiated cells with stem cell identity, but
also to produce new differentiated cells. Initial works revealed that activation of the EMT
program in epithelial cells induces the acquisition of stem cell properties, which in the …
epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and
invasive properties. Stemness is the ability of stem cells to proliferate in an asymmetric way
that allows them to maintain the reservoir of undifferentiated cells with stem cell identity, but
also to produce new differentiated cells. Initial works revealed that activation of the EMT
program in epithelial cells induces the acquisition of stem cell properties, which in the …
New insights into the crossroads between EMT and stemness in the context of cancer
I Fabregat Romero, A Malfettone… - … , 2016, vol. 5, num. 3, p …, 2016 - diposit.ub.edu
The epithelial-mesenchymal transition (EMT) is an example of cellular plasticity, where an
epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and
invasive properties. Stemness is the ability of stem cells to proliferate in an asymmetric way
that allows them to maintain the reservoir of undifferentiated cells with stem cell identity, but
also to produce new differentiated cells. Initial works revealed that activation of the EMT
program in epithelial cells induces the acquisition of stem cell properties, which in the …
epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and
invasive properties. Stemness is the ability of stem cells to proliferate in an asymmetric way
that allows them to maintain the reservoir of undifferentiated cells with stem cell identity, but
also to produce new differentiated cells. Initial works revealed that activation of the EMT
program in epithelial cells induces the acquisition of stem cell properties, which in the …
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