Nitroxide‐Catalyzed Oxidative Amidation of Aldehydes to Yield N‐Acyl Azoles Using Sodium Persulfate
F Politano, A León Sandoval, ML Witko… - European Journal of …, 2022 - Wiley Online Library
F Politano, A León Sandoval, ML Witko, KE Doherty, CM Schroeder, NE Leadbeater
European Journal of Organic Chemistry, 2022•Wiley Online Library… Employing a dual catalytic system of Ru(bpy) 3 (PF 6 ) 2 as a photocatalyst, 2 as the
primary oxidant and sodium persulfate as a terminal oxidant we can perform the oxidative
amidation of aldehydes (Figure 1b) as well as the generation of hexafluoroisopropyl (HFIP)
esters from aldehydes and hexafluoroisopropanol. In the case of the latter, we have
developed a simpler, easier approach that does not require photocatalysis but instead
simply … In summary, we report a methodology for the oxidative amidation of aldehydes to …
primary oxidant and sodium persulfate as a terminal oxidant we can perform the oxidative
amidation of aldehydes (Figure 1b) as well as the generation of hexafluoroisopropyl (HFIP)
esters from aldehydes and hexafluoroisopropanol. In the case of the latter, we have
developed a simpler, easier approach that does not require photocatalysis but instead
simply … In summary, we report a methodology for the oxidative amidation of aldehydes to …
Abstract
A methodology for the oxidative amidation of aldehydes to yield N‐acyl azoles is reported. The approach employs sodium persulfate and a catalytic amount of a nitroxide and is applicable to a range of structurally diverse substrates.
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