No association between the common MTHFR 677C→ T polymorphism and venous thrombosis: results from the MEGA study

ID Bezemer, CJM Doggen, HL Vos… - Archives of internal …, 2007 - jamanetwork.com
… In this article, we report on the association between MTHFR 677C→T and venous thrombosis
in a single large study. The analysis included 4375 patients with a first venous thrombotic …

No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation

GF Del Gobbo, EM Price, CW Hanna, WP Robinson - Clinical Epigenetics, 2018 - Springer
not occur in placentas with the high-risk MTHFR 677TT or 1298CC genotypes. Furthermore,
there was no evidence for an association … of the high-risk MTHFR variants. However, given …

Meta-analysis of MTHFR 677C→ T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential …

SJ Lewis, S Ebrahim, GD Smith - Bmj, 2005 - bmj.com
… This meta-analysis provides no evidence of a causal relation between homocysteine and
coronary heart disease risk in European, North American, and Australian populations …

MTHFR 677C→ T polymorphism and risk of coronary heart disease: a meta-analysis

M Klerk, P Verhoef, R Clarke, HJ Blom, FJ Kok… - Jama, 2002 - jamanetwork.com
… Elucidation of an association, if any, … evidence for or against an association of this
polymorphism and CHD risk. The aim of this study was to assess the relation of the MTHFR 677C→T …

[HTML][HTML] Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C> T polymorphism and blood folate concentrations: a systematic …

BL Tsang, OJ Devine, AM Cordero… - The American journal of …, 2015 - Elsevier
… Given the association of the TT genotype with decreased … of the impact that the MTHFR
677C>T polymorphism may have … was to assess the association between MTHFR genotype and …

Homocysteine, MTHFR 677C→ T polymorphism, and risk of ischemic stroke: results of a meta-analysis

PJ Kelly, J Rosand, JP Kistler, VE Shih, S Silveira… - Neurology, 2002 - AAN Enterprises
… Some of these have reported no evidence of an association, whereas others have reported
a strong link between hyper-Hcy and CVD. Interpretation of the results of these studies as a …

Dose-Related Association of MTHFR 677T Allele With Risk of Ischemic Stroke: Evidence From a Cumulative Meta-Analysis

S Cronin, KL Furie, PJ Kelly - Stroke, 2005 - Am Heart Assoc
… The main finding of this analysis of almost 15 000 subjects is that the MTHFR 677C→T
polymorphism was associated with increased risk of stroke in a graded, dose-dependent fashion. …

[HTML][HTML] ACMG Practice Guideline: lack of evidence for MTHFR polymorphism testing

SE Hickey, CJ Curry, HV Toriello - Genetics in Medicine, 2013 - Elsevier
… loss 51 related to their MTHFR status, common reasons for which … that there is no evidence
of any association with MTHFR “… Strong association of 677 C>T substitution in the MTHFR

Strong Association of 677 C>T Substitution in the MTHFR Gene with Male Infertility - A Study on an Indian Population and a Meta-Analysis

N Gupta, S Gupta, M Dama, A David, G Khanna… - PloS one, 2011 - journals.plos.org
MTHFR) is an important enzyme of folate and methionine metabolism, making it crucial for
DNA synthesis and methylation. The objective of this study was to analyze MTHFR gene 677C

[HTML][HTML] Association between MTHFR 677C> T polymorphism and vitamin B12 deficiency: a case-control study

KM Al-Batayneh, MS Al Zoubi, M Shehab… - Journal of medical …, 2018 - ncbi.nlm.nih.gov
… Our results showed a significant association between homozygous MTHFR c.677C>T
variant and T allele frequencies and vitamin B12 deficiency in the Jordanian population. …