No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia
SA Ivanova, AFY Al Hadithy… - Human …, 2012 - Wiley Online Library
SA Ivanova, AFY Al Hadithy, N Brazovskaya, A Semke, B Wilffert, O Fedorenko…
Human Psychopharmacology: Clinical and Experimental, 2012•Wiley Online LibraryBackground The adenosine A2A receptor forms a heteromeric complex with the striatal
dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A
receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia
was assessed cross‐sectionally in 146 Caucasian psychiatric inpatients from Siberia.
Results Between‐group comparisons of genotypic or allelic frequencies showed no
statistically significant difference. Logistic regression analysis with the occurrence of tardive …
dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A
receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia
was assessed cross‐sectionally in 146 Caucasian psychiatric inpatients from Siberia.
Results Between‐group comparisons of genotypic or allelic frequencies showed no
statistically significant difference. Logistic regression analysis with the occurrence of tardive …
Background
The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia.
Methods
Tardive dyskinesia was assessed cross‐sectionally in 146 Caucasian psychiatric inpatients from Siberia.
Results
Between‐group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype.
Conclusion
The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia. Copyright © 2012 John Wiley & Sons, Ltd.
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