Normal hypothalamic-pituitary-adrenal axis by high-dose cosyntropin testing in patients with abnormal response to low-dose cosyntropin stimulation: a retrospective …
Objective To analyze the interpretation of the 1-μg low-dose adrenocorticotropic hormone
(ACTH) test (LDT) for assessment of the presence of adrenal insufficiency (AI) in comparison
with the 250-μg or standard high-dose ACTH test (HDT), which uses the same cutoff cortisol
value of 18 μg/dL (500 nmol/L) as the lower limit of normal. Methods We present a
retrospective review of 26 patients referred to the Pituitary Clinic who underwent both the
LDT and the HDT for evaluation of the function of the hypothalamic-pituitary-adrenal axis …
(ACTH) test (LDT) for assessment of the presence of adrenal insufficiency (AI) in comparison
with the 250-μg or standard high-dose ACTH test (HDT), which uses the same cutoff cortisol
value of 18 μg/dL (500 nmol/L) as the lower limit of normal. Methods We present a
retrospective review of 26 patients referred to the Pituitary Clinic who underwent both the
LDT and the HDT for evaluation of the function of the hypothalamic-pituitary-adrenal axis …
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