Novel 2, 6-disubstituted pyridine hydrazones: Synthesis, anticancer activity, docking studies and effects on caspase-3-mediated apoptosis
S Şenkardeş, A Türe, S Ekrek, AT Durak… - Journal of Molecular …, 2021 - Elsevier
Novel pyridine-based dihydrazones (3a-l) were synthesized by the condensation of
appropriate aldehydes and pyridine-2, 6-dicarbohydrazide (2) which was obtained by the
treatment of dimethyl pyridine-2, 6-dicarboxylate (1) with hydrazine hydrate. Structures of all
the synthesized compounds were supported by their FTIR, 1 H NMR, 13 C NMR and
microanalytical data. The compounds were screened primarily for their antibacterial
activities as well as anticancer activities. None of the synthesized compounds had important …
appropriate aldehydes and pyridine-2, 6-dicarbohydrazide (2) which was obtained by the
treatment of dimethyl pyridine-2, 6-dicarboxylate (1) with hydrazine hydrate. Structures of all
the synthesized compounds were supported by their FTIR, 1 H NMR, 13 C NMR and
microanalytical data. The compounds were screened primarily for their antibacterial
activities as well as anticancer activities. None of the synthesized compounds had important …
Novel 2, 6-disubstituted pyridine hydrazones: Synthesis, anticancer activity, docking studies and effects on caspase-3-mediated apoptosis
A TÜRE - 2021 - openaccess.marmara.edu.tr
Novel pyridine-based dihydrazones (3a-l) were synthesized by the condensation of
appropriate aldehydes and pyridine-2, 6-dicarbohydrazide (2) which was obtained by the
treatment of dimethyl pyridine-2, 6-dicarboxylate (1) with hydrazine hydrate. Structures of all
the synthesized compounds were supported by their FTIR, H-1 NMR, C-13 NMR and
microanalytical data. The compounds were screened primarily for their antibacterial
activities as well as anticancer activities. None of the synthesized compounds had important …
appropriate aldehydes and pyridine-2, 6-dicarbohydrazide (2) which was obtained by the
treatment of dimethyl pyridine-2, 6-dicarboxylate (1) with hydrazine hydrate. Structures of all
the synthesized compounds were supported by their FTIR, H-1 NMR, C-13 NMR and
microanalytical data. The compounds were screened primarily for their antibacterial
activities as well as anticancer activities. None of the synthesized compounds had important …
以上显示的是最相近的搜索结果。 查看全部搜索结果