Novel Function for Receptor Activity-modifying Proteins (RAMPs) in Post-endocytic Receptor Trafficking*♦
JM Bomberger, N Parameswaran, CS Hall… - Journal of Biological …, 2005 - ASBMB
RAMPs (1–3) are single transmembrane accessory proteins crucial for plasma membrane
expression, which also determine receptor phenotype of various G-protein-coupled
receptors. For example, adrenomedullin receptors are comprised of RAMP2 or RAMP3
(AM1R and AM2R, respectively) and calcitonin receptor-like receptor (CRLR), while a CRLR
heterodimer with RAMP1 yields a calcitonin gene-related peptide receptor. The major aim of
this study was to determine the role of RAMPs in receptor trafficking. We hypothesized that a …
expression, which also determine receptor phenotype of various G-protein-coupled
receptors. For example, adrenomedullin receptors are comprised of RAMP2 or RAMP3
(AM1R and AM2R, respectively) and calcitonin receptor-like receptor (CRLR), while a CRLR
heterodimer with RAMP1 yields a calcitonin gene-related peptide receptor. The major aim of
this study was to determine the role of RAMPs in receptor trafficking. We hypothesized that a …
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