Novel class 1 integron harboring antibiotic resistance genes in wastewater-derived bacteria as revealed by functional metagenomics
BB McGivern, RK McDonell, SK Morris, TM LaPara… - Plasmid, 2021 - Elsevier
Combatting antibiotic resistance is critical to our ability to treat infectious diseases. Here, we
identified and characterized diverse antimicrobial resistance genes, including potentially
mobile elements, from synthetic wastewater treatment microcosms exposed to the
antibacterial agent triclosan. After seven weeks of exposure, the microcosms were subjected
to functional metagenomic selection across 13 antimicrobials. This was achieved by cloning
the combined genetic material from the microcosms, introducing this genetic library into E …
identified and characterized diverse antimicrobial resistance genes, including potentially
mobile elements, from synthetic wastewater treatment microcosms exposed to the
antibacterial agent triclosan. After seven weeks of exposure, the microcosms were subjected
to functional metagenomic selection across 13 antimicrobials. This was achieved by cloning
the combined genetic material from the microcosms, introducing this genetic library into E …
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