Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents
A new series of hybrids of lamellarin D and combretastatin A 4, 1, 2-diphenyl-5, 6-
dihydropyrrolo [2, 1-a] isoquinolines, were designed as cytotoxic agents based on principles
of combination in medicinal chemistry and taking the parent compounds' different anti-
proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized
through a convenient route, with a key step of core pyrrole formation and evaluated for their
anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT …
dihydropyrrolo [2, 1-a] isoquinolines, were designed as cytotoxic agents based on principles
of combination in medicinal chemistry and taking the parent compounds' different anti-
proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized
through a convenient route, with a key step of core pyrrole formation and evaluated for their
anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT …
A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC50 ranges.
Elsevier
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