Diabetes mellitus is a major risk factor for cardiovascular morbidity and mortality. This
condition increases the risk of developing coronary, cerebrovascular, and peripheral arterial
disease fourfold. Endothelial dysfunction is a major contributor to the pathogenesis of
vascular disease in diabetes mellitus patients and has recently received increased attention.
In this review article, some recent developments that could improve the knowledge of
diabetes-induced endothelial dysfunction are discussed.