Background Advancing age progressively impacts on risk and severity of chronic disease. It
also modifies the epigenome, with changes in DNA methylation, due to both random drift
and variation within specific functional loci. Results In a discovery set of 2238 peripheral-
blood genome-wide DNA methylomes aged 19–82 years, we identify 71 age-associated
differentially methylated regions within the linkage disequilibrium blocks of the single
nucleotide polymorphisms from the NIH genome-wide association study catalogue. This …

Background: Advancing age progressively impacts on risk and severity of chronic disease. It
also modifies the epigenome, with changes in DNA methylation, due to both random drift
and variation within specific functional loci. Results: In a discovery set of 2238 peripheral-
blood genome-wide DNA methylomes aged 19-82 years, we identify 71 age-associated
differentially methylated regions within the linkage disequilibrium blocks of the single
nucleotide polymorphisms from the NIH genome-wide association study catalogue. This …