Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network
CA Boettiger, EA Kelley, JM Mitchell… - Pharmacology …, 2009 - Elsevier
Previously, we found that distinct brain areas predict individual selection bias in decisions
between small immediate (“Now”) and larger delayed rewards (“Later”). Furthermore, such
selection bias can be manipulated by endogenous opioid blockade. To test whether
blocking endogenous opioids with naltrexone (NTX) alters brain activity during decision-
making in areas predicting individual bias, we compared fMRI BOLD signal correlated with
Now versus Later decision-making after acute administration of NTX (50 mg) or placebo. We …
between small immediate (“Now”) and larger delayed rewards (“Later”). Furthermore, such
selection bias can be manipulated by endogenous opioid blockade. To test whether
blocking endogenous opioids with naltrexone (NTX) alters brain activity during decision-
making in areas predicting individual bias, we compared fMRI BOLD signal correlated with
Now versus Later decision-making after acute administration of NTX (50 mg) or placebo. We …
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