DNA adducts derived from carcinogenic polycyclic aromatic hydrocarbons like benzo [a]
pyrene (B [a] P) and benzo [c] phenanthrene (B [c] Ph) impede replication and transcription,
resulting in aberrant cell division and gene expression. Global nucleotide excision repair
(NER) and transcription-coupled DNA repair (TCR) are among the DNA repair pathways that
evolved to maintain genome integrity by removing DNA damage. The interplay between
global NER and TCR in repairing the polycyclic aromatic hydrocarbon-derived DNA adducts …