The complicated capillary network induced by angiogenesis is one of the main reasons of
unsuccessful cancer therapy. A multi-scale mathematical method which simulates drug
transport to a solid tumor is used in this study to investigate how capillary network structure
affects drug delivery. The mathematical method involves processes such as blood flow
through vessels, solute and fluid diffusion, convective transport in extracellular matrix, and
extravasation from blood vessels. The effect of heterogeneous dynamic network on …