Flow and heat transfer of nanofluid inside circular and cam-shaped tube bank is studied numerically. Reynolds number for cam-shaped tube bank is defined based on equivalent diameter of circular tube and varies in range of 100 ⩽ Re_D ⩽ 400. Nanofluid is made by adding Al₂O₃ nanoparticle with volume fraction of 1–7% to pure water. Results show using nanofluid results in higher heat transfer rate for both circular tube bank and cam-shaped tube bank. Also, staggered arrangement has higher heat transfer for both circular and cam-shaped tube bank. Pressure drop from cam-shaped tube bank is substantially lower than circular tube bank for all range of Reynolds number and volume fraction.