Obesity increases the risk for high-grade prostate cancer: results from the REDUCE study
AC Vidal, LE Howard, DM Moreira… - … Biomarkers & Prevention, 2014 - AACR
Background: Studies suggest that obesity is associated with lower risk of prostate cancer but
more aggressive cancers. As obesity lowers PSA levels, these observations may be
influenced by detection bias. We examined the association between obesity and risk of low-
and high-grade prostate cancer in REDUCE, in which biopsies were largely independent of
PSA. Methods: The REDUCE study tested dutasteride for prostate cancer risk reduction in
men with a PSA of 2.5 to 10.0 ng/mL and a negative biopsy. Study participants included …
more aggressive cancers. As obesity lowers PSA levels, these observations may be
influenced by detection bias. We examined the association between obesity and risk of low-
and high-grade prostate cancer in REDUCE, in which biopsies were largely independent of
PSA. Methods: The REDUCE study tested dutasteride for prostate cancer risk reduction in
men with a PSA of 2.5 to 10.0 ng/mL and a negative biopsy. Study participants included …
[PDF][PDF] 157 OBESITY INCREASES THE RISK FOR HIGH-GRADE PROSTATE CANCER: RESULTS FROM THE REDUCE STUDY
S Freedland, L Gerber, LL Bañez… - The Journal of …, 2011 - researchgate.net
… How much of these associations result from lower PSA levels in obese men is unclear.
We examined the influence of obesity on risk of low- and high-grade PC in the REDUCE
study, where biopsies were largely independent of PSA. … RESULTS: We analyzed the
data for 17,356 patients with high grade prostate cancer and a documented presenting PSA
value. Patients with a PSA of …
We examined the influence of obesity on risk of low- and high-grade PC in the REDUCE
study, where biopsies were largely independent of PSA. … RESULTS: We analyzed the
data for 17,356 patients with high grade prostate cancer and a documented presenting PSA
value. Patients with a PSA of …
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