Obesity-associated alterations in inflammation, epigenetics, and mammary tumor growth persist in formerly obese mice
Using a murine model of basal-like breast cancer, we tested the hypothesis that chronic
obesity, an established breast cancer risk and progression factor in women, induces
mammary gland epigenetic reprogramming and increases mammary tumor growth.
Moreover, we assessed whether the obesity-induced epigenetic and protumor effects are
reversed by weight normalization. Ovariectomized female C57BL/6 mice were fed a control
diet or diet-induced obesity (DIO) regimen for 17 weeks, resulting in a normal weight or …
obesity, an established breast cancer risk and progression factor in women, induces
mammary gland epigenetic reprogramming and increases mammary tumor growth.
Moreover, we assessed whether the obesity-induced epigenetic and protumor effects are
reversed by weight normalization. Ovariectomized female C57BL/6 mice were fed a control
diet or diet-induced obesity (DIO) regimen for 17 weeks, resulting in a normal weight or …
[PDF][PDF] Obesity-associated alterations in inflammation, epigenetics and mammary tumor growth persist in formerly obese mice
SD Dannenberg - researchgate.net
Using a murine model of basal-like breast cancer, we tested the hypothesis that chronic
obesity, an established breast cancer risk and progression factor in women, induces
mammary gland epigenetic reprogramming and increases mammary tumor growth.
Moreover, we assessed whether the obesity-induced epigenetic and protumor effects are
reversed by weight normalization. Ovariectomized female C57BL/6 mice were fed a control
diet or diet-induced obesity (DIO) regimen for 17 weeks, resulting in a normal weight or …
obesity, an established breast cancer risk and progression factor in women, induces
mammary gland epigenetic reprogramming and increases mammary tumor growth.
Moreover, we assessed whether the obesity-induced epigenetic and protumor effects are
reversed by weight normalization. Ovariectomized female C57BL/6 mice were fed a control
diet or diet-induced obesity (DIO) regimen for 17 weeks, resulting in a normal weight or …
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