Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease
Myelin degeneration and white matter loss resulting from oligodendrocyte (OL) death are
early events in Alzheimer's disease (AD) that lead to cognitive deficits; however, the
underlying mechanism remains unknown. Here, we find that mature OLs in both AD patients
and an AD mouse model undergo NLR family pyrin domain containing 3 (NLRP3)–
dependent Gasdermin D–associated inflammatory injury, concomitant with demyelination
and axonal degeneration. The mature OL-specific knockdown of dynamin-related protein 1 …
early events in Alzheimer's disease (AD) that lead to cognitive deficits; however, the
underlying mechanism remains unknown. Here, we find that mature OLs in both AD patients
and an AD mouse model undergo NLR family pyrin domain containing 3 (NLRP3)–
dependent Gasdermin D–associated inflammatory injury, concomitant with demyelination
and axonal degeneration. The mature OL-specific knockdown of dynamin-related protein 1 …
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