Wine is a special product with a long tradition but it is also strongly influenced by the local soil and climatic conditions of the area where the vineyards are grown, yielding the grapes from which wine is produced. Existing Greek and EU legislation has established a framework of analysis, applied on a sampling basis, with the primary aim of protecting both the consumer and the producers, by safeguarding the wine production process in accordance with scientific principles and current legislation. In the present monograph the available data from analyses carried out on samples from wines produced in Eastern Macedonia and Thrace (located in northern Greece) have been recorded, codified, quoted and processed by the relevant competent authorities of the state, using the sampling procedure provided. The work first analyzes the results produced by the analyses, in order to draw the initial conclusions. The results are then processed using an application for geographical separation, co-variance analysis for the dependent variables, and the creation of time series diagrams. The last two statistical analyses are conducted by exploiting the available climatic parameters of the area. This work has shown the high quality of the wines in the area, the general absence of problems in the wines it produces, and the respect paid to the existing legislation related to winemaking and the use of Protected Geographical Indication (PGI) provisions, since the vast majority of wines produced in the area fall into this category. The statistical analysis of the three methods used yielded indications concerning the separation of wines produced in individual areas, as well as the correlation of wine parameters with climate parameters, and the boundaries of the climatic data where the wine parameters are maximized or minimized. The results are of particular importance in the design of new vineyard installations and wineries, as well as for new wines on the one hand, and the high importance for assessing the impact of the ongoing global changes in climatic conditions on the other. At the same time, these analyses form the basis for further scientific research in order to formulate a modern, efficient, sustainable and developmental policy that includes planning for the development of viticulture and winemaking in the area, and by extension, in any other viticultural area.