On chip magnetic actuator for batch-mode dynamic manipulation of magnetic particles in compact lab-on-chip

R Fulcrand, A Bancaud, C Escriba, Q He… - Sensors and Actuators B …, 2011 - Elsevier
R Fulcrand, A Bancaud, C Escriba, Q He, S Charlot, A Boukabache, AM Gué
Sensors and Actuators B: Chemical, 2011Elsevier
The use of magnetic microbeads in microfluidic systems is a promising approach for setting
up lab on chips that accomplish a variety of bioanalytical operations. To meet the integration
requirements of μTAS, one challenge is to reduce the size of magnetic effectors in order to
increase the complexity of magneto-fluidic systems. In this paper, we report on a new
method for manipulating batches of magnetic microbeads with exquisite spatial precision.
Our approach is based on arrays of individually addressable micro-electromagnetic …
The use of magnetic microbeads in microfluidic systems is a promising approach for setting up lab on chips that accomplish a variety of bioanalytical operations. To meet the integration requirements of μTAS, one challenge is to reduce the size of magnetic effectors in order to increase the complexity of magneto-fluidic systems. In this paper, we report on a new method for manipulating batches of magnetic microbeads with exquisite spatial precision. Our approach is based on arrays of individually addressable micro-electromagnetic actuators, which are integrated in full polymer (SU-8) devices. We define the optimal working range of our technology, demonstrating that 5-turns micro-coils of ∼100μm in dimension efficiently trap 2.8μm microbeads in flow rates of ∼1μL/min. Furthermore we estimate quantitatively the magnetic forces generated by these micro-coils, which are on the order of 1–10pN. Taken together our technology affords reconfigurable and compact solutions for the manipulation of magnetic micro-particles in lab-on-chip applications.
Elsevier
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