… proteins with similar functions to be close together. For this reason, we focus here on protein
sequence and protein … strategy for classifying protein folds depends on specific decisions, …

… and accurate theory of protein structure based on physical and … Extrapolating from folds that
are known to exist, to folds that … new basic folding patterns from membrane proteins, few of …

… provides cosmologists with the principal source of information on the evolution of our planet,
… Our current theoretical understanding of protein folding is insufficient to estimate the total …

… among several proteins, based on the similarity … folds, ie, optimally including all domains
from the same fold in a connected component, whereas excluding from it domains of other folds. …

… a view of protein folds that is based on the … on the arrangement of different types of
secondary-structure elements. By linking the folding process to the organization of the protein …

… folds are most often used in proteins of different organisms. When analyzing the universe
of protein … repository, we have no solid data confirming this assumption on the scale of the …

… study rests on the central assumption that protein folds are … of character evolution is based
on the parsimony principle of … in the distribution and sharing of protein folds across domains, …

… number of protein sequences and the biological information on their … classification of the
protein sequence universe a central task … , a step beyond consecutive modular folding units [46]. …

… Such a systematic approach would provide a very rapid mechanism to complete the repertoire
of protein folds by focusing on the relatively small subset of DUF sequences and families …

… To this end, we focus on the analysis and possible genesis of the protein universe based on
… imply that observed protein folds are not selected based on their physical properties (8). It …