… to NSAIDs. We found little difference in pain reduction between naproxen and low-dose
colchicine, but naproxen … , naproxen should be used ahead of low-dose colchicine to treat gout …

… compared with the 23% seen in the low- dose colchicine arm in the Acute Gout Flare Receiving
Colchicine Evaluation (AGREE) trial.… , we believe that NSAIDs and colchicine have an …

… versus placebo found that naproxen did not significantly increase major vascular events or
… to other NSAIDs.We acknowledge that the colchicine dose in our pragmatic trial differed from …

… that although a lower dose colchicine is likely also effective, … this study to compare naproxen
and low dose colchicine and … a randomized, multi-center, open label pragmatic clinical trial…

… to other NSAIDs.3 We acknowledge that the colchicine dose in our pragmatic trial differed
… Pragmatic trials evaluate interventions as prescribed, managed and used in routine clinical …

… were often excluded due to contraindications to naproxen. … group of standard care receives
low-dose colchicine (day 1: 1.5 … for a randomized controlled clinical trial comparing colchicine …

… Prednisolone and low-dose colchicine were selected for this … to day 3 with treatment of
naproxen or colchicine. Therefore, the … After 4 weeks, the patients are contacted via telephone by …

… aimed to compare the safety and short-term equivalence of low-dose colchicine with oral …
by the investigator (oral colchicine, oral prednisone, NSAIDs, intra-articular corticosteroids, or …

… difference in efficacy between low- dose colchicine and NSAIDs treatments. Moreover, …
Open- label randomised pragmatic trial (CONTACT) comparing naproxen and lowdose colchicine …

… One small open-label study reported that patients treated with topical ice therapy in … The
CONTACT trial indicates similar efficacy of naproxen 750 mg/day and low-dose colchicine (0.5 …