The impact of COVID-19 has been disproportionately felt by populations experiencing structural racial- and ethnicity-based discrimination. Here, we describe opportunities for COVID-19 response and recovery efforts to help build more equal and resilient societies, through investments in: (i) interventions focused on explicitly addressing racial and ethnicity-based discrimination; (ii) interventions supporting the delivery of universal services, and in ways that address compounding and intersecting drivers of exclusion and marginalization; and (iii) cross-cutting enabling measures, such as participatory mechanisms and data disaggregation.