The present studies discuss about the optimization and in-vitro and in-vivo evaluation of floating tablet of tetrabenazine. For designing a dosage form with consistent and controlled residence in the stomach, an important strategic consideration is selection of suitable excipient. Floating properties of dosage forms is anticipated to be improved by using high molecular weight and less hydrophilic polymers. Non-effervescent systems can be developed by using number of polymers including swellable and gel forming cellulose derivative hydrocolloids as well as matrix formers (eg hydroxypropyl methylcellulose, hydroxyethyl cellulose, and Ethyl Cellulose). For creation of a suitable dosage form excipients and APIs are mixed to form powder blends followed by compressing in to solid oral (tablet) dosage forms.