[HTML][HTML] Optimization of spinal manipulative therapy protocols: a factorial randomized trial within a multiphase optimization framework
Spinal manipulative therapy (SMT) is a common nonpharmacological treatment for low back
pain (LBP). Although generally supported by systematic reviews and practice guidelines,
clinical trials evaluating SMT have been characterized by small effect sizes. This study
adopts a Multiphase Optimization Strategy framework to examine individual components of
an SMT delivery protocol using a single-blind trial with the goal of identifying and optimizing
a multicomponent SMT protocol. We enrolled 241 participants with LBP. All participants …
pain (LBP). Although generally supported by systematic reviews and practice guidelines,
clinical trials evaluating SMT have been characterized by small effect sizes. This study
adopts a Multiphase Optimization Strategy framework to examine individual components of
an SMT delivery protocol using a single-blind trial with the goal of identifying and optimizing
a multicomponent SMT protocol. We enrolled 241 participants with LBP. All participants …
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