[HTML][HTML] Optimized clade 2.3. 2.1 c H5N1 recombinant-vaccine strains against highly pathogenic avian influenza
Abstract A/Puerto Rico/8/34 (PR8)-derived recombinant viruses have been used for
seasonal flu vaccines; however, they are insufficient for vaccines against some human-fatal
H5N1 highly pathogenic avian influenza (HPAI) viruses (HPAIV) due to low productivity.
Additionally, the polymerase basic 2 (PB2) protein, an important mammalian-pathogenicity
determinant, of PR8 possesses several mammalian-pathogenic mutations. We previously
reported two avian PB2 genes (01310 and 0028) related to efficient replication in …
seasonal flu vaccines; however, they are insufficient for vaccines against some human-fatal
H5N1 highly pathogenic avian influenza (HPAI) viruses (HPAIV) due to low productivity.
Additionally, the polymerase basic 2 (PB2) protein, an important mammalian-pathogenicity
determinant, of PR8 possesses several mammalian-pathogenic mutations. We previously
reported two avian PB2 genes (01310 and 0028) related to efficient replication in …
Optimized clade 2.3. 2.1 c H5N1 recombinant-vaccine strains against highly pathogenic avian influenza.
JJW Jang JinWook, LCY Lee ChungYoung… - 2017 - cabidigitallibrary.org
Abstract A/Puerto Rico/8/34 (PR8)-derived recombinant viruses have been used for
seasonal flu vaccines; however, they are insufficient for vaccines against some human-fatal
H5N1 highly pathogenic avian influenza (HPAI) viruses (HPAIV) due to low productivity.
Additionally, the polymerase basic 2 (PB2) protein, an important mammalian-pathogenicity
determinant, of PR8 possesses several mammalian-pathogenic mutations. We previously
reported two avian PB2 genes (01310 and 0028) related to efficient replication in …
seasonal flu vaccines; however, they are insufficient for vaccines against some human-fatal
H5N1 highly pathogenic avian influenza (HPAI) viruses (HPAIV) due to low productivity.
Additionally, the polymerase basic 2 (PB2) protein, an important mammalian-pathogenicity
determinant, of PR8 possesses several mammalian-pathogenic mutations. We previously
reported two avian PB2 genes (01310 and 0028) related to efficient replication in …