Oral antibiotics reduce voluntary exercise behavior in athletic mice

MP McNamara, MD Cadney, AA Castro, DA Hillis… - Behavioural …, 2022 - Elsevier
The gut microbiome can affect various aspects of both behavior and physiology, including
exercise ability, but effects on voluntary exercise have rarely been studied. We studied
females from a selection experiment in which 4 replicate High Runner (HR) lines of mice are
bred for voluntary exercise and compared with 4 non-selected control (C) lines. HR and C
mice differ in several traits that likely interact with the gut microbiome, including higher daily
running distance, body temperatures when running, spontaneous physical activity when …
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