Potentially, the most useful method of fish vaccination is oral administration. However, this
technique is presently only partially effective because of the apparent destruction of the
vaccine in the fish digestive system, as well as interaction of the vaccine with the feed
components. The authors' approach to this problem was to protect the vaccine by entrapping
it within semi-permeable biocompatible microcapsules. Two bioactive agents—a vaccine,
Vibrio bacterin and a model protein, bovine serum albumin (BSA)—were entrapped in …