Oral immunization with a novel attenuated Salmonella Typhimurium encoding influenza HA, M2e and NA antigens protects chickens against H7N9 infection
Attenuated Salmonella strains constitute a promising technology for the development of
efficient protein-based influenza vaccines. H7N9, a low pathogenic avian influenza (LPAI)
virus, is a major public health concern and currently there are no effective vaccines against
this subtype. Herein, we constructed a novel attenuated Salmonella Typhimurium strain for
the delivery and expression of H7N9 hemagglutinin (HA), neuraminidase (NA) or the
conserved extracellular domain of the matrix protein 2 (M2e). We demonstrated that the …
efficient protein-based influenza vaccines. H7N9, a low pathogenic avian influenza (LPAI)
virus, is a major public health concern and currently there are no effective vaccines against
this subtype. Herein, we constructed a novel attenuated Salmonella Typhimurium strain for
the delivery and expression of H7N9 hemagglutinin (HA), neuraminidase (NA) or the
conserved extracellular domain of the matrix protein 2 (M2e). We demonstrated that the …
Oral immunization with a novel attenuated Salmonella Typhimurium encoding influenza HA, M2e and NA antigens protects chickens against H7N9 infection.
KJH Kim JeHyoung, IA Hajam, HJ Lee Hwa [Lee - 2018 - cabidigitallibrary.org
Attenuated Salmonella strains constitute a promising technology for the development of
efficient protein-based influenza vaccines. H7N9, a low pathogenic avian influenza (LPAI)
virus, is a major public health concern and currently there are no effective vaccines against
this subtype. Herein, we constructed a novel attenuated Salmonella Typhimurium strain for
the delivery and expression of H7N9 hemagglutinin (HA), neuraminidase (NA) or the
conserved extracellular domain of the matrix protein 2 (M2e). We demonstrated that the …
efficient protein-based influenza vaccines. H7N9, a low pathogenic avian influenza (LPAI)
virus, is a major public health concern and currently there are no effective vaccines against
this subtype. Herein, we constructed a novel attenuated Salmonella Typhimurium strain for
the delivery and expression of H7N9 hemagglutinin (HA), neuraminidase (NA) or the
conserved extracellular domain of the matrix protein 2 (M2e). We demonstrated that the …
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