Osteocalcin and serum insulin-like growth factor-1 as biochemical skeletal maturity indicators
T Tripathi, P Gupta, P Rai, J Sharma, VK Gupta… - Progress in …, 2017 - Springer
T Tripathi, P Gupta, P Rai, J Sharma, VK Gupta, N Singh
Progress in Orthodontics, 2017•SpringerBackground With change in concepts of growth determination methods, there is a surge in
the measurement of biomarkers for appraisal of growth status. Osteocalcin is a bone-specific
protein and was observed to parallel the normal growth curve. Hence, the present study was
intended to assess the levels of serum osteocalcin and serum insulin-like growth factor-1
(IGF-1) and compare them with cervical vertebral maturation index (CVMI) stages. Methods
The cross-sectional study was performed on 150 subjects (75 males and 75 females) in the …
the measurement of biomarkers for appraisal of growth status. Osteocalcin is a bone-specific
protein and was observed to parallel the normal growth curve. Hence, the present study was
intended to assess the levels of serum osteocalcin and serum insulin-like growth factor-1
(IGF-1) and compare them with cervical vertebral maturation index (CVMI) stages. Methods
The cross-sectional study was performed on 150 subjects (75 males and 75 females) in the …
Background
With change in concepts of growth determination methods, there is a surge in the measurement of biomarkers for appraisal of growth status. Osteocalcin is a bone-specific protein and was observed to parallel the normal growth curve. Hence, the present study was intended to assess the levels of serum osteocalcin and serum insulin-like growth factor-1 (IGF-1) and compare them with cervical vertebral maturation index (CVMI) stages.
Methods
The cross-sectional study was performed on 150 subjects (75 males and 75 females) in the age group of 8–20 years and segregated into six CVMI stages. Serum osteocalcin and IGF-1 were estimated by ELISA. Mann-Whitney U test was used to compare the mean ranks of serum osteocalcin and serum IGF-1 with different CVMI stages. Spearman correlation was performed to find association between serum osteocalcin and serum IGF-1 across six CVMI stages.
Results
Peak serum IGF-1 levels were obtained at CVMI stages 4 and 3 for males and females, respectively, with insignificant difference between stages 3 and 4 in females. Peak serum osteocalcin levels were found at stage 5 and 3 for males and females with insignificant difference from other stages except stages 5 and 6 in males. A statistically significant correlation was seen between serum IGF-1 and serum osteocalcin across six CVMI stages (P < 0.01).
Conclusions
Osteocalcin followed IGF-1 across all CVMI stages but showed insignificant interstage differences.
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