Osteomacs and bone regeneration

L Batoon, SM Millard, LJ Raggatt, AR Pettit - Current osteoporosis reports, 2017 - Springer
… unit (BMU) on the bone endosteal surface in which osteomacs are adjacent to cuboidal …
the bone surface (arrowhead). c–d Images showing presence of F4/80 + TRAP neg osteomacs

OsteoMacs: Key players around bone biomaterials

RJ Miron, DD Bosshardt - Biomaterials, 2016 - Elsevier
… of OsteoMacs led to significantly reduced intramembranous ossification bone healing
whereas administration of CSF-1 in the animal models led to an increase in OsteoMac number at …

[HTML][HTML] OsteoMac: a new player on the bone biology scene

IV Oscar, GFT Francisco, FT Isabel, LB Isabel… - Annals of Anatomy …, 2024 - Elsevier
… They observed that CD169 + OMs depletion was associated with impaired bone healing via
endochondral ossification, concluding that CD169 + OMs were crucial for normal periosteal …

Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

KA Alexander, MK Chang, ER Maylin… - Journal of Bone and …, 2011 - academic.oup.com
… This study establishes osteomacs as participants in intramembranous bone healing and as
… of osteomacs to intramembranous ossification using a mouse model of bone healing.22 We …

Macrophages and bone remodeling

MM Weivoda, EW Bradley - … of Bone and Mineral Research, 2023 - academic.oup.com
bone regeneration, be it divergent or redundant, is poorly understood. Induction of osteomacs
at sites of skeletal injury may be a therapeutic avenue to aid tissue healing in the setting of …

Osteomacs support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model

L Batoon, SM Millard, LJ Raggatt, AC Wu, S Kaur… - bioRxiv, 2021 - biorxiv.org
… , we observed that osteomac loss was associated with elevated extracellular TRAP in bone
marrow … Fracture in ovariectomised C3H/HeJ mice is associated with delayed bone healing

Resting and injury‐induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration

KA Alexander, LJ Raggatt, S Millard… - Immunology and cell …, 2017 - Wiley Online Library
… , including osteomacs, within the periosteum during a bone healing time course … bone
dynamics as well as bone repair/regeneration. Herein we definitively demonstrate that osteomacs

Osteoinduction and osteoimmunology: Emerging concepts

RJ Miron, M Bohner, Y Zhang… - Periodontology …, 2024 - Wiley Online Library
… interplay of osteal macrophages (OsteoMacs) and their key role around bone biomaterials.…
during bone regeneration (Figure 1). This article summarizes their role in bone regeneration

The multifaceted roles of macrophages in bone regeneration: a story of polarization, activation and time

C Schlundt, H Fischer, CH Bucher, C Rendenbach… - Acta biomaterialia, 2021 - Elsevier
… or even redundant functions during bone regeneration. Inflammatory macrophages express
… on non-inflammatory osteomacs. In intramembranous bone healing, osteomacs appeared …

ThE macrophage's role on bone remodeling and osteogenesis: a systematic review

JM Orvalho, JCH Fernandes, R Moraes Castilho… - … Reviews in Bone and …, 2023 - Springer
… in bone tissue, also called osteomacs which make up one-sixth of all cells in bone marrow
[15], suggesting that these cells could also be involved in the bone regeneration process. This …