Amyloids are associated with many neurodegenerative diseases, motivating investigations
into their structure and function. Although not linked to a specific disease, albumins have
been reported to form many structural aggregates. We were interested in investigating host
immune responses to amyloid fibrils assembled from the model protein ovalbumin.
Surprisingly, upon subjecting ovalbumin to standard denaturing conditions, we encountered
giant protein nanosheets harboring amyloid-like features and hypothesized that these …