Ovariectomy increases neuronal amyloid-β binding alcohol dehydrogenase level in the mouse hippocampus
E Fukuzaki, K Takuma, Y Funatsu, Y Himeno… - Neurochemistry …, 2008 - Elsevier
Ovarian hormone decline after menopause may influence cognitive performance and
increase the risk for Alzheimer's disease (AD) in women. Amyloid-β peptide (Aβ) has been
proposed to be the primary cause of AD. In this study, we examined whether ovariectomy
(OVX) could affect the levels of cofactors Aβ-binding alcohol dehydrogenase (ABAD) and
receptor for advanced glycation endproducts (RAGE), which have been reported to
potentiate Aβ-mediated neuronal perturbation, in mouse hippocampus, correlating with …
increase the risk for Alzheimer's disease (AD) in women. Amyloid-β peptide (Aβ) has been
proposed to be the primary cause of AD. In this study, we examined whether ovariectomy
(OVX) could affect the levels of cofactors Aβ-binding alcohol dehydrogenase (ABAD) and
receptor for advanced glycation endproducts (RAGE), which have been reported to
potentiate Aβ-mediated neuronal perturbation, in mouse hippocampus, correlating with …
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