Oxidative coupling of enolates using memory of chirality: an original enantioselective synthesis of quaternary α-amino acid derivatives
A Mambrini, D Gori, R Guillot, C Kouklovsky… - Chemical …, 2018 - pubs.rsc.org
A Mambrini, D Gori, R Guillot, C Kouklovsky, V Alezra
Chemical Communications, 2018•pubs.rsc.org… We describe here the first enantioselective oxidative heterocoupling of enolates. Our
strategy relies on the … We wanted to extend our strategy to radical reactions in order to
enlarge its scope, our aim being to achieve oxidation of the intermediate enolate into a
stabilized captodative radical. In this paper, we report our efforts towards enantioselective
oxidative heterocoupling of enolates using memory of chirality and consequently describe
the first enantioselective version of this reaction. …
strategy relies on the … We wanted to extend our strategy to radical reactions in order to
enlarge its scope, our aim being to achieve oxidation of the intermediate enolate into a
stabilized captodative radical. In this paper, we report our efforts towards enantioselective
oxidative heterocoupling of enolates using memory of chirality and consequently describe
the first enantioselective version of this reaction. …
We describe here the first enantioselective oxidative heterocoupling of enolates. Our strategy relies on the memory of chirality concept and allows the stereocontrolled formation of quaternary centres on α-amino acid derivatives with an enantiomeric excess of up to 94%.
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