Neuropeptides collaborate with conventional neurotransmitters to regulate synaptic output.
Pituitary adenylate cyclase-activating polypeptide (PACAP) co-localizes with acetylcholine
in presynaptic nerve terminals, is released by stimulation, and enhances nicotinic
acetylcholine receptor-(nAChR-) mediated responses. Such findings implicate PACAP in
modulating nicotinic neurotransmission, but relevant synaptic mechanisms have not been
explored. We show here that PACAP acts via selective high-affinity G-protein coupled …