PLTP deficiency improves the anti-inflammatory properties of HDL and reduces the ability of LDL to induce monocyte chemotactic activity
We reported that phospholipid transfer protein (PLTP) deficiency decreased atherosclerosis
in mouse models. Because the decreased atherosclerosis was accompanied by a significant
decrease in plasma HDL levels, we examined the properties of PLTP knockout (PLTP0)
HDL and tested its ability to prevent LDL-induced monocyte chemotactic activity in human
artery wall cell cocultures. We isolated HDL and LDL from LDL receptor knockout/PLTP
knockout (LDLr0/PLTP0) mice and from apolipoprotein B transgenic (apoBTg)/PLTP0 mice …
in mouse models. Because the decreased atherosclerosis was accompanied by a significant
decrease in plasma HDL levels, we examined the properties of PLTP knockout (PLTP0)
HDL and tested its ability to prevent LDL-induced monocyte chemotactic activity in human
artery wall cell cocultures. We isolated HDL and LDL from LDL receptor knockout/PLTP
knockout (LDLr0/PLTP0) mice and from apolipoprotein B transgenic (apoBTg)/PLTP0 mice …
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