PPAR agonists protect mesangial cells from interleukin 1β-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway
XZ Ruan, JF Moorhead, R Fernando… - Journal of the …, 2003 - journals.lww.com
Previous studies have demonstrated that inflammatory cytokines such as interleukin-1β (IL-
1β) promote lipid accumulation in human mesangial cells (HMC) by dysregulating the
expression of lipoprotein receptors. Intracellular lipid accumulation is governed by both
influx and efflux; therefore, the effect of IL-1β on the efflux of lipid from HMC was
investigated. IL-1β was shown to inhibit 3 H-cholesterol efflux from HMC and increase total
intracellular cholesterol concentration, probably as a result of reduced expression of the …
1β) promote lipid accumulation in human mesangial cells (HMC) by dysregulating the
expression of lipoprotein receptors. Intracellular lipid accumulation is governed by both
influx and efflux; therefore, the effect of IL-1β on the efflux of lipid from HMC was
investigated. IL-1β was shown to inhibit 3 H-cholesterol efflux from HMC and increase total
intracellular cholesterol concentration, probably as a result of reduced expression of the …
以上显示的是最相近的搜索结果。 查看全部搜索结果