PTTG and cancer

T Hamid, SS Kakar - Histology and histopathology, 2003 - digitum.um.es
… , pttg is degraded and daughter cells express little pttg. The degradation of pttg occurs via
ubiquitin since pttg … on these findings and the importance of pttg protein in various cancers, …

PTTG: an important target gene for ovarian cancer therapy

SK Panguluri, C Yeakel, SS Kakar - Journal of ovarian research, 2008 - Springer
cancer cells and most tumors express high levels of PTTG. Overexpression of PTTG in
vitro induces cellular transformation and development of tumors in nude mice. The PTTG

[HTML][HTML] Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients

CC Wu, TI Ekanem, NN Phan, SY Hou… - … Journal of Medical …, 2020 - ncbi.nlm.nih.gov
cancer tumorigenesis is still an open question. Therefore, in the present study, we explored
roles of PTTG members in breast cancer … of family members in breast cancer as well as their …

Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer

ML Read, JC Fong, B Modasia, A Fletcher… - Oncogene, 2017 - nature.com
… with PBF and PTTG expression in … /PTTG expression and mutationally activated BRAF.
Together our findings indicate that PBF and PTTG have a critical role in promoting thyroid cancer

Expression of PTTG (pituitary tumor transforming gene) in esophageal cancer

Y Shibata, N Haruki, Y Kuwabara… - Japanese Journal of …, 2002 - academic.oup.com
… In this paper, we have reported that PTTG is highly expressed in esophageal cancer
compared with normal mucosa, as reported in pituitary tumors and other neoplasms. …

PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility

C Zhou, Y Tong, K Wawrowsky, S Melmed - Oncogene, 2014 - nature.com
… and PTTG are upregulated in several cancers, we assessed confocal immunofluorescence
patterns of STAT3 and PTTG … Normal tissue STAT3 and PTTG immunoreactivity was weak or …

Suppression of lung cancer with siRNA targeting PTTG

SS Kakar, MT Malik - International Journal of Oncology, 2006 - spandidos-publications.com
… of PTTG in various lung tumors and tumor-derived cell lines. For a better understanding of
its role in maintaining the cancer … In conclusion, decreasing PTTG expression through PTTG

PTTG overexpression promotes lymph node metastasis in human esophageal squamous cell carcinoma

S Yan, C Zhou, X Lou, Z Xiao, H Zhu, Q Wang, Y Wang… - Cancer research, 2009 - AACR
… Nevertheless, the molecular mechanisms of PTTG action are still unclear. We have …
PTTG (14). In this study, we present evidence that PTTG overexpression in esophageal cancer

[HTML][HTML] PTTG promotes invasion in human breast cancer cell line by upregulating EMMPRIN via FAK/Akt/mTOR signaling

H Gao, F Zhong, J Xie, J Peng, Z Han - American journal of cancer …, 2016 - ncbi.nlm.nih.gov
… of PTTG overexpression on … PTTG gene is strongly associated with breast cancer metastasis.
Moreover, our findings suggested that PTTG enhances metastatic potential of breast cancer

[Retracted] Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer

X Li, Y Tai, S Liu, Y Gao, K Zhang, J Yin… - Stem Cells …, 2023 - Wiley Online Library
… the mRNA expressions of PTTG family members in STAD carcinoma tissues and the correlations
between these expressions and the presence or absence of cancer in the lymph nodes. …