Paclitaxel loaded poly-d, l-lactide-co-glycolide nanoparticles: enhanced anticancer effect in non-small cell lung carcinoma cell line
JPJ Merlin, B Venkadesh, R Hussain… - … & Preventive Nutrition, 2013 - Elsevier
The aim of the present study was to develop PTX-PLGA nanoparticles and to study its
anticancer efficacy in NCI-H460 cells in vitro. DLS results revealed that prepared PTX-PLGA
had an average size of 211 nm. TEM analysis showed that prepared PTX-PLGA
nanoparticles were spherical in shape with 150 nm. Drug encapsulation assay showed that
65% PTX was encapsulated in PLGA. It was noticed that anticancer potential of PTX-PLGA
nanoparticles was greater than that of PTX treatment alone. Further, PLGA-PTX exhibits …
anticancer efficacy in NCI-H460 cells in vitro. DLS results revealed that prepared PTX-PLGA
had an average size of 211 nm. TEM analysis showed that prepared PTX-PLGA
nanoparticles were spherical in shape with 150 nm. Drug encapsulation assay showed that
65% PTX was encapsulated in PLGA. It was noticed that anticancer potential of PTX-PLGA
nanoparticles was greater than that of PTX treatment alone. Further, PLGA-PTX exhibits …
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