A PEG based hydrogel and a procedure for its topical application to the surface of the pia
mater of the spinal cord that can be used for intrathecal delivery of diverse drug and
biomolecular therapies for the treatment of traumatic central nervous system injuries and
disorders including spinal cord injury (SCI), multiple sclerosis (MS) and amyotrophic lateral
sclerosis (ALS) are provided. This “painting of the pia” with biofunctionalized hydrogel
material may be used as a prelude strategy in the therapeutic management of these CNS …