Palladium-catalyzed carbonylative cross-coupling reaction between aryl (heteroaryl) iodides and tricyclopropylbismuth: expedient access to aryl cyclopropylketones
E Benoit, J Dansereau, A Gagnon - Synlett, 2017 - thieme-connect.com
E Benoit, J Dansereau, A Gagnon
Synlett, 2017•thieme-connect.comThe carbonylative cross-coupling reaction between aryl and heteroaryl iodides and
tricyclopropylbismuth is reported. The reaction is catalyzed by (SIPr) Pd (allyl) Cl, a NHC-
palladium (II) catalyst, operates under 1 atm of carbon monoxide and tolerates a wide range
of functional groups. The use of lithium chloride was found to provide higher yields of the
desired aryl cyclopropylketones. The conditions were also applied to the carbonylative cross-
coupling of an iodoalkene to afford the corresponding alkenyl cyclopropylketone.
tricyclopropylbismuth is reported. The reaction is catalyzed by (SIPr) Pd (allyl) Cl, a NHC-
palladium (II) catalyst, operates under 1 atm of carbon monoxide and tolerates a wide range
of functional groups. The use of lithium chloride was found to provide higher yields of the
desired aryl cyclopropylketones. The conditions were also applied to the carbonylative cross-
coupling of an iodoalkene to afford the corresponding alkenyl cyclopropylketone.
The carbonylative cross-coupling reaction between aryl and heteroaryl iodides and tricyclopropylbismuth is reported. The reaction is catalyzed by (SIPr)Pd(allyl)Cl, a NHC-palladium(II) catalyst, operates under 1 atm of carbon monoxide and tolerates a wide range of functional groups. The use of lithium chloride was found to provide higher yields of the desired aryl cyclopropylketones. The conditions were also applied to the carbonylative cross-coupling of an iodoalkene to afford the corresponding alkenyl cyclopropylketone.
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