Panax notoginseng saponins attenuate cardiomyocyte apoptosis through mitochondrial pathway in natural aging rats

Z Zhou, J Wang, Y Song, Y He, C Zhang… - Phytotherapy …, 2018 - Wiley Online Library
Panax notoginseng saponins (PNS) have been widely used in the cardiovascular system for
the treatment of cardiovascular diseases and stroke in China. In this study, we investigated
the anti‐apoptotic effect of PNS on cardiomyocytes in the natural aging rat and explored the
potential mechanisms regarding oxidative stress and mitochondrial function signaling
pathways. Male Sprague–Dawley rats were randomly divided into five groups: adult control
(3‐month old), aging control (24‐month old), and different doses of PNS‐treated aging rat …

Panax notoginseng saponins attenuate cardiomyocyte apoptosis through mitochondrial pathway in natural aging rats.

ZZY Zhou ZhiYong, WJ Wang Jiao, SYN Song YaNan… - 2018 - cabidigitallibrary.org
Panax notoginseng saponins (PNS) have been widely used in the cardiovascular system for
the treatment of cardiovascular diseases and stroke in China. In this study, we investigated
the anti-apoptotic effect of PNS on cardiomyocytes in the natural aging rat and explored the
potential mechanisms regarding oxidative stress and mitochondrial function signaling
pathways. Male Sprague-Dawley rats were randomly divided into five groups: adult control
(3-month old), aging control (24-month old), and different doses of PNS-treated aging rat …
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