Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions
Activating transcription factor 6 (ATF6) is one of three principle endoplasmic reticulum (ER)
stress response proteins and becomes activated when ER homeostasis is perturbed. ATF6
functions to increase ER capacity by stimulating transcription of ER-resident chaperone
genes such as GRP78. Using an antibody that recognizes active ATF6α-p50, we found that
active ATF6α was detected in insulinoma cells and rodent islets even under basal conditions
and the levels were further increased by ER stress. To examine the function of ATF6α-p50 …
stress response proteins and becomes activated when ER homeostasis is perturbed. ATF6
functions to increase ER capacity by stimulating transcription of ER-resident chaperone
genes such as GRP78. Using an antibody that recognizes active ATF6α-p50, we found that
active ATF6α was detected in insulinoma cells and rodent islets even under basal conditions
and the levels were further increased by ER stress. To examine the function of ATF6α-p50 …
“PANCREATIC β-CELLS DEPEND ON BASAL EXPRESSION OF ACTIVE ATF6α-2 p50 FOR CELL SURVIVAL EVEN UNDER NON-STRESS CONDITIONS». 3
E Chevet - 2012 - journals.physiology.org
… active form of ATF6α (ATF6α-p50) the authors find that active/cleaved ATF6α-p50 is 33
detected in under basal conditions insulinoma cell lines and rodent islets. As 34 … the
same phenotype is also observed upon overexpression of the active ATF6α-p50 39 …
detected in under basal conditions insulinoma cell lines and rodent islets. As 34 … the
same phenotype is also observed upon overexpression of the active ATF6α-p50 39 …