COVID-19 has had unprecedented effects on populations around the world. Given the political context of the pandemic and the nation’s response to it, this study sought to assess the extent of Americans’ personal fear about the virus as well as their fear for others (altruistic fear), identify potential predictors of these fears, and examine the mental health impact of heightened COVID-19 fears. Overall, a majority of respondents worried about various aspects of the virus, from being exposed to dying, and reported often worrying about others, including family, the elderly, and healthcare professionals. Building on the fear of crime literature, we find that certain individuals, including those who believe they are at a high risk of dying from the virus, non-Whites, and those who closely follow news coverage of the pandemic, are likely to experience elevated fear and, possibly, its consequences.