Paracoccin induces M1 polarization of macrophages via interaction with TLR4
The fungal human pathogen Paracoccidioides brasiliensis contains paracoccin (PCN), a
multi-domain protein that has lectin and N-acetyl-glucosaminidase activities, which account
for its effects on the growth and morphogenesis of the fungus and on the activation of host
macrophages through its interaction with TLR N-glycans. With the purpose of detailing the
knowledge on the effects of PCN on macrophages, we used recombinant PCN expressed in
Pichia pastoris (p-rPCN) to stimulate isolated murine peritoneal macrophages. The …
multi-domain protein that has lectin and N-acetyl-glucosaminidase activities, which account
for its effects on the growth and morphogenesis of the fungus and on the activation of host
macrophages through its interaction with TLR N-glycans. With the purpose of detailing the
knowledge on the effects of PCN on macrophages, we used recombinant PCN expressed in
Pichia pastoris (p-rPCN) to stimulate isolated murine peritoneal macrophages. The …
[引用][C] Paracoccin induces M1 polarization of macrophages via interaction with TLR4. Front Microbiol 7: 1003
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