complication of severe brain injury. It is characterized by episodic hypertension,
hyperthermia, tachycardia, tachypnea, diaphoresis, and specific posturing. It is prevalent in
an intensive care unit (ICU) setting where high acuity illnesses can mask the symptoms of
PSH. Herein, we report a case of PSH in a patient with a past medical history significant for
glioblastoma multiforme (GBM) status post hemicraniectomy, radiation, and chemotherapy.