Introduction: Paroxysmal kinesigenic dyskinesia (PKD) is a rare movement disorder triggered by sudden voluntary movements. The disorder involves attacks of chorea, which resolve within minutes, that may occur frequently throughout the day. Case Presentation: A 61-year-old woman presented to the clinic with a 13-year history of PKD first diagnosed in 2002. This patient had frequent episodic attacks of PKD, which were so severe she had difficulty with ambulation and other activities of daily living. The case was complicated by an additional diagnosis of chronic fatigue syndrome. She refused antiseizure medication because of concerns about it exacerbating her fatigue. In the office, she was given weekly parenteral doses of vitamins and minerals, which almost completely eliminated her symptoms between treatments and allowed her to return to activities of daily living.

Discussion: Genetic testing, not related to her PKD diagnosis, revealed several mutations that could offer an explanation for the apparent efficacy of parenteral therapy in this patient.