Pathological gambling is linked to reduced activation of the mesolimbic reward system
J Reuter, T Raedler, M Rose, I Hand, J Gläscher… - Nature …, 2005 - nature.com
Nature neuroscience, 2005•nature.com
By analogy to drug dependence, it has been speculated that the underlying pathology in
pathological gambling is a reduction in the sensitivity of the reward system. Studying
pathological gamblers and controls during a guessing game using functional magnetic
resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal
activation in the pathological gamblers that was negatively correlated with gambling
severity, linking hypoactivation of these areas to disease severity.
pathological gambling is a reduction in the sensitivity of the reward system. Studying
pathological gamblers and controls during a guessing game using functional magnetic
resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal
activation in the pathological gamblers that was negatively correlated with gambling
severity, linking hypoactivation of these areas to disease severity.
Abstract
By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.
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